منابع مشابه
Linkage Disequilibrium in Wild Mice
Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have been identified. The main difficulty is the extensive linkage disequilibrium (LD) in intercross progeny and the slow process of fine-scale mapp...
متن کاملThe Gut Microbiota of Wild Mice
The gut microbiota profoundly affects the biology of its host. The composition of the microbiota is dynamic and is affected by both host genetic and many environmental effects. The gut microbiota of laboratory mice has been studied extensively, which has uncovered many of the effects that the microbiota can have. This work has also shown that the environments of different research institutions ...
متن کاملNucleotide variation in wild and inbred mice.
The house mouse is a well-established model organism, particularly for studying the genetics of complex traits. However, most studies of mice use classical inbred strains, whose genomes derive from multiple species. Relatively little is known about the distribution of genetic variation among these species or how variation among strains relates to variation in the wild. We sequenced intronic reg...
متن کاملGenetic and Molecular Analysis of Wild-Derived Arrhythmic Mice
A new circadian variant was isolated by screening the intercross offspring of wild-caught mice (Mus musculus castaneus). This variant was characterized by an initial maintenance of damped oscillations and subsequent loss of rhythmicity after being transferred from light-dark (LD) cycles to constant darkness (DD). To map the genes responsible for the persistence of rhythmicity (circadian ratio) ...
متن کاملA stochastic model of social interaction in wild house mice
We investigate to what extent the interaction dynamics of a population of wild house mouse (Mus musculus domesticus) in their environment can be explained by a simple stochastic model. We use a Markov chain model to describe the transitions of mice in a discrete space of nestboxes, and implement a multi-agent simulation of the model. We find that some important features of our behavioural datas...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2018
ISSN: 0093-7355,1548-4475
DOI: 10.1038/s41684-018-0082-z